DESCRIPTION / DEFINITIONS: Klonopin® (clonazepam) is a benzodiazepine prescribed for the management of anxiety disorders and for seizures.
ABUSE: Klonopin has a high dependence/addiction and abuse among many users. Attempts to withdraw from Klonopin will result in many withdrawal symptoms.
ADDICTION / DEPENDENCE: Half life and metabolism.
SIDE EFFECTS: Confusion, suicide ideation/attempt, impotence (see list below).
WITHDRAWAL SYMPTOMS: Anxiety, psychosis, headache (see list below).
TREATMENT: Medical detoxification.
Klonopin® (clonazepam) is a benzodiazepine. According to its label, “The precise mechanism by which clonazepam exerts its antiseizure and antipanic effects is unknown, although it is believed to be related to its ability to enhance the activity of gamma aminobutyric acid (GABA), the major inhibitory neurotransmitter in the central nervous system.”
Klonopin has a high dependence/addiction and abuse among many users. Attempts to withdraw from Klonopin will result in many withdrawal symptoms.
HALF LIFE AND METABOLISM
The biological half life of a substance is the time it takes for a drug to lose half of its pharmacologic activity. This is significant because it affects how soon withdrawal symptoms may appear.
The half life of Klonopin is between 30-40 hours.
Klonopin is mainly metabolized through the P450 pathway in the liver and the enzyme primarily handling the metabolism is CYP3A but it is not clear how much of the metabolism is done by other enzymes.
The CYP enzymes are the major enzymes involved in drug metabolism, and since many drugs may increase or decrease the activity of various CYP isozymes, this is a major source of adverse drug interactions, since changes in CYP enzyme activity may affect the metabolism and clearance of various drugs. For example, if one drug inhibits the CYP-mediated metabolism of another drug, the second drug may accumulate within the body to toxic levels, possibly causing an overdose.
The following information is taken from the Klonopin label:
- allergic skin reactions
- anaphylactic/oid reactions
- autonomic manifestations
- blurred vision
- change in appetite
- change in libido
- CNS effects
- decreased orgasm
- dermatological symptoms
- extrapyramidal symptoms
- eye-function/visual disturbance
- hypersensitivity reactions
- increase in alkaline phosphatase
- increase in bilirubin
- increase in liver transaminases
- memory impairment
- respiratory depression
- sexual arousal
- sleep disturbances/insomnia
- slurred speech
- small decreases in blood pressure
- suicidal ideation/attempt
- worsening of obstructive pulmonary disease
- worsening of sleep apnea
Klonopin can be a very difficult drug to stop taking.
- digestive problems
- loss of appetite
- muscle aches
- panic attacks
- sleeplessness, nightmares
Withdrawal from Klonopin should only be done under the care of a health practitioner. The safest way is to withdraw at an inpatient medical detox facility with a protocol that includes hydration, vitamins and supplements for biological balancing. Call us to talk to a Detox Advisor.